Addition of enoximone to adrenergic agents in the management of severe heart failure

OBJECTIVETo assess the hemodynamic effects of the addition of small bolus doses of the phos-phodiesterase inhibitor enoximone to adrenergic therapy in patients with severe heart failure. DESIGNOpen label, prospective study. SETTINGMultidisciplinary department of intensive care in a university academ...

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Veröffentlicht in:	Critical care medicine 1992-08, Vol.20 (8), p.1102-1106
Hauptverfasser:	VINCENT, JEAN-LOUIS, LÉON, MARC, BERRÉ, JACQUES, MÉLOT, CHRISTIAN, KAHN, ROBERT J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Analysis of Variance Biological and medical sciences Cardiotonic agents Cardiotonic Agents - administration & dosage Cardiotonic Agents - adverse effects Cardiovascular system Critical Care Medicine Drug Evaluation Drug Therapy, Combination Enoximone Female General & Internal Medicine Heart Failure - drug therapy Heart Failure - physiopathology Hemodynamics - drug effects Humans Imidazoles - administration & dosage Imidazoles - adverse effects Infusions, Intravenous Life Sciences & Biomedicine Male Medical sciences Middle Aged Pharmacology. Drug treatments Phosphodiesterase Inhibitors - administration & dosage Phosphodiesterase Inhibitors - adverse effects Postoperative Care Prospective Studies Science & Technology Sympathomimetics - therapeutic use
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Zusammenfassung:	OBJECTIVETo assess the hemodynamic effects of the addition of small bolus doses of the phos-phodiesterase inhibitor enoximone to adrenergic therapy in patients with severe heart failure. DESIGNOpen label, prospective study. SETTINGMultidisciplinary department of intensive care in a university academic hospital. PATIENTSTwelve surgical patients after cardiac surgery and ten medical patients with ischemic or dilated cardiomyopathy who had signs of altered tissue perfusion associated with a low cardiac index (
ISSN:	0090-3493 1530-0293
DOI:	10.1097/00003246-199208000-00006