CHROMATOGRAPHIC RESOLUTION OF RACEMIC AMINES, CARBOXYLIC-ACIDS, AND ALCOHOLS BY A NEW HOMOCHIRAL REAGENT DERIVED FROM ENDO-BORNEOL

CHROMATOGRAPHIC RESOLUTION OF RACEMIC AMINES, CARBOXYLIC-ACIDS, AND ALCOHOLS BY A NEW HOMOCHIRAL REAGENT DERIVED FROM ENDO-BORNEOL

Chromatographic separation of racemic amines, carboxylic acids and alcohols can be achieved with excellent resolution as measured in terms of the chromatographic separation factor-alpha by derivatization with a homochiral oxazolidin-2-one easily prepared in three steps from endo-borneol. The resolve...

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Veröffentlicht in:Chromatographia 1992-07, Vol.34 (1-2), p.48-50
Hauptverfasser: BANKS, MR, CADOGAN, JIG, DAWSON, IM, GOSNEY, GRANT, KJ, GAUR, S, HODGSON, PKG, STEVENSON, DE
Format: Artikel
Sprache:eng
Schlagworte:
Analytical chemistry
Biochemical Research Methods
Biochemistry & Molecular Biology
Chemistry
Chemistry, Analytical
Chromatographic methods and physical methods associated with chromatography
Exact sciences and technology
Life Sciences & Biomedicine
Other chromatographic methods
Physical Sciences
Science & Technology
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Zusammenfassung:Chromatographic separation of racemic amines, carboxylic acids and alcohols can be achieved with excellent resolution as measured in terms of the chromatographic separation factor-alpha by derivatization with a homochiral oxazolidin-2-one easily prepared in three steps from endo-borneol. The resolved materials can be isolated in excellent yields by cleavage of the resultant diastereomers using conventional methods, which also allow recovery of the chiral resolving agent for re-use.
ISSN:0009-5893
1612-1112
DOI:10.1007/BF02290458