Synthesis of chemically stable 9-substituted carbacyclin derivatives and their biological use

Synthesis of chemically stable 9-substituted carbacyclin derivatives and their biological use

A variety of 9-substituted carbacyclin derivatives was synthesized and their biological properties evaluated. It is shown that a triple bond directly attached to the bicyclo[3.3.O]system resulted in biologically very active derivatives, one of which was successfully used to establish a highly select...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 1992, Vol.2 (5), p.439-444
Hauptverfasser: Deicke, P., Klar, H., Vorbrüggen, H.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry, Medicinal
Chemistry, Organic
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Physical Sciences
Science & Technology
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Zusammenfassung:A variety of 9-substituted carbacyclin derivatives was synthesized and their biological properties evaluated. It is shown that a triple bond directly attached to the bicyclo[3.3.O]system resulted in biologically very active derivatives, one of which was successfully used to establish a highly selective and sensitive radio-immuno-assay (RIA) for Iloprost. Several 9-substituted carbacyclin derivatives were synthesized and their biological properties evaluated.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)80165-1