Neurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities

Cerebrovascular abnormality is linked to Alzheimer's disease and related dementias (ADRDs). ApoE-.4 (APOE4) is known to play a critical role in neurovascular dysfunction, however current medical imaging technologies are limited in quantification. This cross-sectional study tested the feasibilit...

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Veröffentlicht in:	PloS one 2021-08, Vol.16 (8), p.e0256749-e0256749, Article 0256749
Hauptverfasser:	Leaston, Joshua, Ferris, Craig F., Kulkarni, Praveen, Chandramohan, Dharshan, van de Ven, Anne L., Qiao, Ju, Timms, Liam, Sepulcre, Jorge, El Fakhri, Georges, Ma, Chao, Normandin, Marc D., Gharagouzloo, Codi
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Alzheimer's disease Amygdala Animal models Animals Apolipoprotein E Apolipoprotein E4 Apolipoprotein E4 - genetics Biology and Life Sciences Blood Blood circulation disorders Blood vessels Blood-Brain Barrier - diagnostic imaging Blood-Brain Barrier - pathology Brain Brain - abnormalities Brain - blood supply Brain - diagnostic imaging Brain research Cerebellum Circuits Comparative analysis Dementia Diagnosis Disease Models, Animal Evaluation Feasibility studies Gene Knock-In Techniques Genetic aspects Hospitals Humans Magnetic resonance Magnetic Resonance Imaging Medical imaging Medical schools Medicine and Health Sciences Multidisciplinary Sciences Neurodegenerative diseases Neuroimaging Pathology Rats Rattus Research and Analysis Methods Science & Technology Science & Technology - Other Topics Vascularization Wages & salaries
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Zusammenfassung:	Cerebrovascular abnormality is linked to Alzheimer's disease and related dementias (ADRDs). ApoE-.4 (APOE4) is known to play a critical role in neurovascular dysfunction, however current medical imaging technologies are limited in quantification. This cross-sectional study tested the feasibility of a recently established imaging modality, quantitative ultra-short time-to-echo contrast-enhanced magnetic resonance imaging (QUTE-CE MRI), to identify small vessel abnormality early in development of human APOE4 knock-in female rat (TGRA8960) animal model. At 8 months, 48.3% of the brain volume was found to have significant signal increase (75/173 anatomically segmented regions; q
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0256749