Synthesis of aminoisoquinolines via Rh-catalyzed [4 + 2] annulation of benzamidamides with vinylene carbonate

A new strategy is developed for the synthesis of 1-aminoisoquinoline derivatives. This Rh(III)-catalyzed [4 + 2] annulation reaction employs benzamidines as efficient directing groups and the vinylene carbonate as an acetylene surrogate. Additionally, the reaction features broad substrate scopes and good yields, only producing carbonate anion as byproduct. A new strategy is developed for the synthesis of 1-aminoisoquinoline derivatives, employing benzamidines as efficient directing groups and the vinylene carbonate as an acetylene surrogate. The reaction features broad substrate scopes and good yields, only producing carbonate anion as byproduct. [Display omitted]