Developmental biology: A 5 ' Hoxd-Gli3 balance in tetrapod axial polarity

Almost all living tetrapods exhibit postaxial dominance in digit formation, apart from urodele amphibians, which show preaxial dominance. Recent work shines light on the genetic differences between the two modes of limb development, suggesting that differences in 5'Hoxd expression, mediated by...

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Veröffentlicht in:	Current biology 2021-11, Vol.31 (22), p.R1487-R1490
Hauptverfasser:	Royle, Samantha R., Young, John J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry & Molecular Biology Biology Cell Biology Life Sciences & Biomedicine Life Sciences & Biomedicine - Other Topics Science & Technology
Online-Zugang:	Volltext
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Zusammenfassung:	Almost all living tetrapods exhibit postaxial dominance in digit formation, apart from urodele amphibians, which show preaxial dominance. Recent work shines light on the genetic differences between the two modes of limb development, suggesting that differences in 5'Hoxd expression, mediated by Gli3, may explain the switch in axial polarity.
ISSN:	0960-9822 1879-0445
DOI:	10.1016/j.cub.2021.10.031