Oxidative Stress and Cardiometabolic Disorders

The authors clearly demonstrated that orosomucid 1, an acute-phase protein, attenuated inflammation and ischemic stroke in an animal model via upregulation of nuclear factor-like 2 (Nrf2) and suppression of heme oxygenase 1 (HO-1) [12]. The study in the fourth article “Qiliqiangxin Improves Cardiac Function through Regulating Energy Metabolism via HIF-1α-Dependent and Independent Mechanisms in Heart Failure Rats after Acute Myocardial Infarction,” authored by Y. Wang et al. was designed to evaluate the influence of Qiliqiangxin, QL, on energy metabolism in experimental myocardial infarction and the role of hypoxia-inducible factor 1α (HIF-1α) signaling [19]. Acute myocardial infarction (AMI) was established by ligating the left anterior descending coronary artery in adult male Sprague Dawley rats, and animals with an ejection fraction