Potentiality of α-fetoprotein (AFP) and soluble intercellular adhesion molecule-1 (sICAM-1) in prognosis prediction and immunotherapy response for patients with hepatocellular carcinoma

The α-fetoprotein (AFP) and soluble intercellular adhesion molecule-1 (sICAM-1) have certain diagnostic value, but their potential value in prognosis prediction, especially immunotherapy response prediction, remains unclear in liver cancer. Through the tumor-free survival (TFS) and overall survival...

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Veröffentlicht in:	Bioengineered 2021-12, Vol.12 (2), p.9435-9451
Hauptverfasser:	Cao, Weiwei, Chen, Yu, Han, Wei, Yuan, Juzheng, Xie, Weimin, Liu, Kun, Qiu, Yan, Wang, Xudan, Li, Xiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged alpha-Fetoproteins - immunology alpha-Fetoproteins - metabolism Biotechnology & Applied Microbiology Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - immunology Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - therapy Disease-Free Survival Female Humans Immunotherapy immunotherapy response Intercellular Adhesion Molecule-1 - blood Intercellular Adhesion Molecule-1 - immunology Life Sciences & Biomedicine Liver Neoplasms - blood Liver Neoplasms - immunology Liver Neoplasms - mortality Liver Neoplasms - therapy Male Middle Aged Neoplasm Proteins - blood Neoplasm Proteins - immunology prognosis prediction Research Paper Science & Technology soluble intercellular adhesion molecule-1 Survival Rate α-fetoprotein
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Zusammenfassung:	The α-fetoprotein (AFP) and soluble intercellular adhesion molecule-1 (sICAM-1) have certain diagnostic value, but their potential value in prognosis prediction, especially immunotherapy response prediction, remains unclear in liver cancer. Through the tumor-free survival (TFS) and overall survival (OS) rates analyses of serum AFP and sICAM-1 levels in 87 patients with primary hepatocellular carcinoma (HCC), the patients whose AFP and sICAM-1 levels were normal (AFP < 20 μg/L or sICAM-1
ISSN:	2165-5979 2165-5987
DOI:	10.1080/21655979.2021.1990195