Electrochemically mediated trifluoromethylation of 2H-indazole derivatives using CF3SO2Na

Electrochemically mediated trifluoromethylation of 2H-indazole derivatives using CF3SO2Na

[Display omitted] An environmentally friendly method of electrochemical mediated regioselective C-3 trifluoromethylation of 2H-indazole by employing CF3SO2Na as the CF3 source was described. This reaction tolerated various functional groups and provided CH trifluoromethylated products in moderate to...

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Veröffentlicht in:Tetrahedron letters 2021-12, Vol.86, p.153313, Article 153313
Hauptverfasser: Wei, Tingting, Wang, Kai, Yu, Zhichen, Hou, Jiahao, Xie, Yuanyuan
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry, Organic
Electrochemical
Environment friendly
Indazole
Physical Sciences
Regioselectivity
Science & Technology
Trifluoromethylation
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Zusammenfassung:[Display omitted] An environmentally friendly method of electrochemical mediated regioselective C-3 trifluoromethylation of 2H-indazole by employing CF3SO2Na as the CF3 source was described. This reaction tolerated various functional groups and provided CH trifluoromethylated products in moderate to good yields under transition metal-free and oxidant-free reaction conditions. Mechanism experiments showed that a radical process might be involved in this transformation.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2021.153313