Cardiac functions in children with growth hormone deficiency: Effects of one year of GH replacement therapy

Cardiac functions in children with growth hormone deficiency: Effects of one year of GH replacement therapy

Children with Growth Hormone deficiency (GHD) are prone to heart dysfunction and, if left untreated, will result in marked cardiac dysfunction in adulthood. The aim was to evaluate the effect of GHD and growth hormone (GH) therapy on cardiac structure in children and adolescents, and to investigate...

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Veröffentlicht in:Growth hormone & IGF research 2021-10, Vol.60-61, p.101432-101432, Article 101432
Hauptverfasser: Alkan, Fatos, Ersoy, Betul, Kızılay, Deniz Ozalp, Coskun, Senol
Format: Artikel
Sprache:eng
Schlagworte:
Cardiovascular Diseases - etiology
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - pathology
Case-Control Studies
Cell Biology
Child
Dwarfism, Pituitary - drug therapy
Dwarfism, Pituitary - pathology
Echocardiography
Endocrinology & Metabolism
Female
Follow-Up Studies
Growth hormone
Growth hormone deficiency
Hormone Replacement Therapy - adverse effects
Human Growth Hormone - adverse effects
Human Growth Hormone - deficiency
Humans
Insulin-Like Growth Factor I - metabolism
Life Sciences & Biomedicine
Male
Myocardial performance index
Prognosis
Prospective Studies
Risk Factors
Science & Technology
Tissue Doppler imaging
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Zusammenfassung:Children with Growth Hormone deficiency (GHD) are prone to heart dysfunction and, if left untreated, will result in marked cardiac dysfunction in adulthood. The aim was to evaluate the effect of GHD and growth hormone (GH) therapy on cardiac structure in children and adolescents, and to investigate the role of insulin like growth factor-1 (IGF-1) in this. M-mode, pulse-wave Doppler echocardiography and tissue Doppler imaging (TDI) were performed in 49 children with GHD who were divided into those with a peak GH response 
ISSN:1096-6374
1532-2238
DOI:10.1016/j.ghir.2021.101432