Glucose Metabolic Alteration of Cerebral Cortical Subareas in Rats with Renal Ischemia/Reperfusion Based on Small-Animal Positron Emission Tomography

Objective To investigate glucose metabolic alterations in cerebral cortical subareas using 18 F-labeled glucose derivative fluorodeoxyglucose (FDG) micro-positron emission tomography (PET) scanning in a rat renal ischemia/reperfusion (RIR) model. Methods Small-animal PET imaging in vivo was performed with 18 F-labeled FDG as a PET tracer to identify glucose metabolic alterations in cerebral cortical subregions using a rat model of RIR. Results We found that the average standardized uptake value (SUV average ) of the cerebral cortical subareas in the RIR group was significantly increased compared to the sham group ( P