Zn2+-Dependent peptide nucleic acid-based artificial ribonucleases with unprecedented efficiency and specificity

Zn2+-Dependent peptide nucleic acid-based artificial ribonucleases with unprecedented efficiency and specificity

We present Zn2+-dependent dimethyl-dipyridophenazine PNA conjugates as efficient RNA cleaving artificial enzymes. These PNAzymes display site-specific RNA cleavage with 10 minute half-lives and cleave clinically relevant RNA models.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2021-10, Vol.57 (83), p.10911-10914
Hauptverfasser: Luige, Olivia, Bose, Partha Pratim, Stulz, Rouven, Steunenberg, Peter, Brun, Omar, Andersson, Shalini, Murtola, Merita, Stromberg, Roger
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry, Multidisciplinary
Medicin och hälsovetenskap
Nucleic acids
Physical Sciences
Ribonucleic acid
RNA
Science & Technology
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Zusammenfassung:We present Zn2+-dependent dimethyl-dipyridophenazine PNA conjugates as efficient RNA cleaving artificial enzymes. These PNAzymes display site-specific RNA cleavage with 10 minute half-lives and cleave clinically relevant RNA models.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d1cc04383h