The Central Role of PAI-1 in COVID-19: Thrombosis and beyond

Khan discuss the central role of PAI-1 in COVID-19. The discovery of medical therapies to reduce morbidity and mortality related to coronavirus disease (COVID-19) remains an area of intense investigation. Han and Pandey describe an elegant set of in vitro experiments to investigate cellular mechanis...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2021-09, Vol.65 (3), p.238-240
1. Verfasser:	Khan, Sadiya S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry & Molecular Biology Cell Biology Coronaviruses COVID-19 Endothelial cells Life Sciences & Biomedicine Medical treatment Microvasculature Morbidity Mortality Proteins Respiratory System Science & Technology Severe acute respiratory syndrome coronavirus 2 Spike protein Thrombosis
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Zusammenfassung:	Khan discuss the central role of PAI-1 in COVID-19. The discovery of medical therapies to reduce morbidity and mortality related to coronavirus disease (COVID-19) remains an area of intense investigation. Han and Pandey describe an elegant set of in vitro experiments to investigate cellular mechanisms underlying SARS-CoV-2-triggered endothelial dysfunction in human pulmonary microvascular endothelial cells (HPMECs). The central finding of their work is the robust release of PAI-1 by HPMECs in response to the uptake of recombinant SARS-CoV-2 spike protein (S1).
ISSN:	1044-1549 1535-4989
DOI:	10.1165/rcmb.2021-0208ED