Ventilation settings in preterm neonates with ventilator-dependant, evolving bronchopulmonary dysplasia

Ventilation settings in preterm neonates with ventilator-dependant, evolving bronchopulmonary dysplasia

The only guidance in the literature on which tidal volumes to use when ventilating babies with, or at high risk of, bronchopulmonary dysplasia (BPD) suggests using very large volume breaths of around 8–12 mL/kg and low rates (10–20 breaths per min) to achieve adequate gas exchange, whilst acknowledg...

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Veröffentlicht in:Early human development 2021-08, Vol.159, p.105417-105417, Article 105417
Hauptverfasser: O'Connor, Kristin L., Davies, Mark W.
Format: Artikel
Sprache:eng
Schlagworte:
Bronchopulmonary dysplasia
Life Sciences & Biomedicine
Obstetrics & Gynecology
Pediatrics
Preterm infants
Science & Technology
Ventilation strategies
Ventilator-dependant
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Zusammenfassung:The only guidance in the literature on which tidal volumes to use when ventilating babies with, or at high risk of, bronchopulmonary dysplasia (BPD) suggests using very large volume breaths of around 8–12 mL/kg and low rates (10–20 breaths per min) to achieve adequate gas exchange, whilst acknowledging there are no data to validate these strategies. The aim of this retrospective, observational, cohort study was to identify the mechanical ventilation settings that are used, and what carbon dioxide (CO2) levels were achieved, in neonates with ventilator-dependant evolving BPD. This retrospective cohort study included neonates born
ISSN:0378-3782
1872-6232
DOI:10.1016/j.earlhumdev.2021.105417