Characterization of high-H2O2-tolerant bacterial cytochrome P450 CYP105D18: insights into papaverine N-oxidation

The bacterial CYP105 family is involved in secondary metabolite biosynthetic pathways and plays essential roles in the biotransformation of xenobiotics. This study investigates the newly identified H2O2-mediated CYP105D18 from Streptomyces laurentii as the first bacterial CYP for N-oxidation. The ca...

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Veröffentlicht in:	IUCrJ 2021-07, Vol.8 (4), p.684-694
Hauptverfasser:	Pardhe, Bashu Dev, Do, Hackwon, Jeong, Chang-Sook, Kim, Ki-Hwa, Lee, Jun Hyuck, Oh, Tae-Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Biotransformation Chemistry Chemistry, Multidisciplinary co-crystals crystal morphology Crystallography cyp105d18 Cytochromes P450 enzyme mechanisms h2o2 tolerance Hydrogen peroxide Materials Science Materials Science, Multidisciplinary Metabolites Oxidation Oxidation rate papaverine n-oxide Physical Sciences Research Papers Science & Technology streptomyces laurentii Structural analysis Substrates Technology
Online-Zugang:	Volltext
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