Association between the rs3733846 in the flanking region of miR-143/145 and risk of cervical squamous cell carcinoma
To investigate the effect of rs3733846 in the flanking region of miR-143/145 on susceptibility to cervical squamous cell carcinoma (CSCC). We collected venous blood samples from 242 CSCC patients and 250 healthy controls. The rs3733846 polymorphism was genotyped by SnaPshot and Sanger sequencing. Th...
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| Veröffentlicht in: | Biomarkers in medicine 2021-08, Vol.15 (11), p.891-897 |
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| container_title | Biomarkers in medicine |
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| creator | Gong, Jianyu Jiang, Jike Qu, Jianwen Li, Ju Chen, Xin Ruan, Zhiguo Lu, Gangxu He, Yuxiao He, Xiaoshan Sun, Ruifen |
| description | To investigate the effect of rs3733846 in the flanking region of miR-143/145 on susceptibility to cervical squamous cell carcinoma (CSCC).
We collected venous blood samples from 242 CSCC patients and 250 healthy controls. The rs3733846 polymorphism was genotyped by SnaPshot and Sanger sequencing. The expression of miR-143/145 in CSCC tissues was detected by quantitative real-time PCR.
The rs3733846 AG genotype was associated with a decreased risk of CSCC in genetic model (AGvs.AA: adjusted odds ratio [OR]: 0.44; 95% CI: 0.30–0.66; p < 0.001). Patients with the rs3733846 AG/GG genotypes had a reduced risk of developing poorly differential status (OR: 0.57; 95% CI: 0.33–0.98; p < 0.04) and lymph node metastasis (OR: 0.49; 95% CI: 0.26–0.92; p < 0.03).
The rs3733846 in the flanking region of miR-143/145 was related to the susceptibility of CSCC. |
| doi_str_mv | 10.2217/bmm-2020-0865 |
| format | Article |
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We collected venous blood samples from 242 CSCC patients and 250 healthy controls. The rs3733846 polymorphism was genotyped by SnaPshot and Sanger sequencing. The expression of miR-143/145 in CSCC tissues was detected by quantitative real-time PCR.
The rs3733846 AG genotype was associated with a decreased risk of CSCC in genetic model (AGvs.AA: adjusted odds ratio [OR]: 0.44; 95% CI: 0.30–0.66; p < 0.001). Patients with the rs3733846 AG/GG genotypes had a reduced risk of developing poorly differential status (OR: 0.57; 95% CI: 0.33–0.98; p < 0.04) and lymph node metastasis (OR: 0.49; 95% CI: 0.26–0.92; p < 0.03).
The rs3733846 in the flanking region of miR-143/145 was related to the susceptibility of CSCC.</description><identifier>ISSN: 1752-0363</identifier><identifier>ISSN: 1752-0371</identifier><identifier>EISSN: 1752-0371</identifier><identifier>DOI: 10.2217/bmm-2020-0865</identifier><identifier>PMID: 34229450</identifier><language>eng</language><publisher>LONDON: Future Medicine Ltd</publisher><subject>Adult ; Carcinoma, Squamous Cell - genetics ; Case-Control Studies ; cervical squamous cell carcinoma ; Female ; Genetic Predisposition to Disease - genetics ; Genotype ; Humans ; Life Sciences & Biomedicine ; Medicine, Research & Experimental ; MicroRNAs - genetics ; Middle Aged ; miR-143/145 ; Polymorphism, Single Nucleotide ; qPCR ; Research & Experimental Medicine ; Risk Factors ; Science & Technology ; single-nucleotide polymorphism ; Uterine Cervical Neoplasms - genetics</subject><ispartof>Biomarkers in medicine, 2021-08, Vol.15 (11), p.891-897</ispartof><rights>2021 Future Medicine Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>0</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000670268700001</woscitedreferencesoriginalsourcerecordid><cites>FETCH-LOGICAL-c299t-c66a28e82b14101230d77565ee02e8f69a5cce0aea77b3d05562d5ae52e338403</cites><orcidid>0000-0001-8967-2011</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930,39263</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34229450$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gong, Jianyu</creatorcontrib><creatorcontrib>Jiang, Jike</creatorcontrib><creatorcontrib>Qu, Jianwen</creatorcontrib><creatorcontrib>Li, Ju</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Ruan, Zhiguo</creatorcontrib><creatorcontrib>Lu, Gangxu</creatorcontrib><creatorcontrib>He, Yuxiao</creatorcontrib><creatorcontrib>He, Xiaoshan</creatorcontrib><creatorcontrib>Sun, Ruifen</creatorcontrib><title>Association between the rs3733846 in the flanking region of miR-143/145 and risk of cervical squamous cell carcinoma</title><title>Biomarkers in medicine</title><addtitle>BIOMARK MED</addtitle><addtitle>Biomark Med</addtitle><description>To investigate the effect of rs3733846 in the flanking region of miR-143/145 on susceptibility to cervical squamous cell carcinoma (CSCC).
We collected venous blood samples from 242 CSCC patients and 250 healthy controls. The rs3733846 polymorphism was genotyped by SnaPshot and Sanger sequencing. The expression of miR-143/145 in CSCC tissues was detected by quantitative real-time PCR.
The rs3733846 AG genotype was associated with a decreased risk of CSCC in genetic model (AGvs.AA: adjusted odds ratio [OR]: 0.44; 95% CI: 0.30–0.66; p < 0.001). Patients with the rs3733846 AG/GG genotypes had a reduced risk of developing poorly differential status (OR: 0.57; 95% CI: 0.33–0.98; p < 0.04) and lymph node metastasis (OR: 0.49; 95% CI: 0.26–0.92; p < 0.03).
The rs3733846 in the flanking region of miR-143/145 was related to the susceptibility of CSCC.</description><subject>Adult</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Case-Control Studies</subject><subject>cervical squamous cell carcinoma</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Humans</subject><subject>Life Sciences & Biomedicine</subject><subject>Medicine, Research & Experimental</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>miR-143/145</subject><subject>Polymorphism, Single Nucleotide</subject><subject>qPCR</subject><subject>Research & Experimental Medicine</subject><subject>Risk Factors</subject><subject>Science & Technology</subject><subject>single-nucleotide polymorphism</subject><subject>Uterine Cervical Neoplasms - genetics</subject><issn>1752-0363</issn><issn>1752-0371</issn><issn>1752-0371</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNkd9r1zAUxYsobk4ffZU8ClJ3c9Mk7eP44i8YCKLPJU1vZ1ybbEm64X9varfvm-BTbg6fczk5qarXHN4jcn0-LEuNgFBDq-ST6pRriTUIzZ8eZyVOqhcp_QKQWit8Xp2IBrFrJJxW-SKlYJ3JLng2UL4n8iz_JBaT0EK0jWJuF6bZ-Gvnr1ikqw0OE1vct5o34pw3khk_sujS9aZbinfOmpml29UsYU1FmWdmTbTOh8W8rJ5NZk706uE8q358_PD98Lm-_Prpy-HisrbYdbm2ShlsqcWBNxw4Chi1lkoSAVI7qc5IawkMGa0HMYKUCkdpSCJtyUGcVW_3vTcx3K6Ucr-4tEUxnkqqHmXTIXCNqqD1jtoYUoo09TfRLSb-7jn0W9F9Kbrfiu63ogv_5mH1Oiw0HunHZgvwbgfuaQhTso68pSMGAEoDqlaXCXih2_-nDy7__a9DWH0u1m63TmteIz1691uJ5krn9I9X_AG2vKtU</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Gong, Jianyu</creator><creator>Jiang, Jike</creator><creator>Qu, Jianwen</creator><creator>Li, Ju</creator><creator>Chen, Xin</creator><creator>Ruan, Zhiguo</creator><creator>Lu, Gangxu</creator><creator>He, Yuxiao</creator><creator>He, Xiaoshan</creator><creator>Sun, Ruifen</creator><general>Future Medicine Ltd</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8967-2011</orcidid></search><sort><creationdate>20210801</creationdate><title>Association between the rs3733846 in the flanking region of miR-143/145 and risk of cervical squamous cell carcinoma</title><author>Gong, Jianyu ; Jiang, Jike ; Qu, Jianwen ; Li, Ju ; Chen, Xin ; Ruan, Zhiguo ; Lu, Gangxu ; He, Yuxiao ; He, Xiaoshan ; Sun, Ruifen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c299t-c66a28e82b14101230d77565ee02e8f69a5cce0aea77b3d05562d5ae52e338403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Case-Control Studies</topic><topic>cervical squamous cell carcinoma</topic><topic>Female</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Humans</topic><topic>Life Sciences & Biomedicine</topic><topic>Medicine, Research & Experimental</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>miR-143/145</topic><topic>Polymorphism, Single Nucleotide</topic><topic>qPCR</topic><topic>Research & Experimental Medicine</topic><topic>Risk Factors</topic><topic>Science & Technology</topic><topic>single-nucleotide polymorphism</topic><topic>Uterine Cervical Neoplasms - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gong, Jianyu</creatorcontrib><creatorcontrib>Jiang, Jike</creatorcontrib><creatorcontrib>Qu, Jianwen</creatorcontrib><creatorcontrib>Li, Ju</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Ruan, Zhiguo</creatorcontrib><creatorcontrib>Lu, Gangxu</creatorcontrib><creatorcontrib>He, Yuxiao</creatorcontrib><creatorcontrib>He, Xiaoshan</creatorcontrib><creatorcontrib>Sun, Ruifen</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomarkers in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gong, Jianyu</au><au>Jiang, Jike</au><au>Qu, Jianwen</au><au>Li, Ju</au><au>Chen, Xin</au><au>Ruan, Zhiguo</au><au>Lu, Gangxu</au><au>He, Yuxiao</au><au>He, Xiaoshan</au><au>Sun, Ruifen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between the rs3733846 in the flanking region of miR-143/145 and risk of cervical squamous cell carcinoma</atitle><jtitle>Biomarkers in medicine</jtitle><stitle>BIOMARK MED</stitle><addtitle>Biomark Med</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>15</volume><issue>11</issue><spage>891</spage><epage>897</epage><pages>891-897</pages><issn>1752-0363</issn><issn>1752-0371</issn><eissn>1752-0371</eissn><abstract>To investigate the effect of rs3733846 in the flanking region of miR-143/145 on susceptibility to cervical squamous cell carcinoma (CSCC).
We collected venous blood samples from 242 CSCC patients and 250 healthy controls. The rs3733846 polymorphism was genotyped by SnaPshot and Sanger sequencing. The expression of miR-143/145 in CSCC tissues was detected by quantitative real-time PCR.
The rs3733846 AG genotype was associated with a decreased risk of CSCC in genetic model (AGvs.AA: adjusted odds ratio [OR]: 0.44; 95% CI: 0.30–0.66; p < 0.001). Patients with the rs3733846 AG/GG genotypes had a reduced risk of developing poorly differential status (OR: 0.57; 95% CI: 0.33–0.98; p < 0.04) and lymph node metastasis (OR: 0.49; 95% CI: 0.26–0.92; p < 0.03).
The rs3733846 in the flanking region of miR-143/145 was related to the susceptibility of CSCC.</abstract><cop>LONDON</cop><pub>Future Medicine Ltd</pub><pmid>34229450</pmid><doi>10.2217/bmm-2020-0865</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-8967-2011</orcidid></addata></record> |
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| subjects | Adult Carcinoma, Squamous Cell - genetics Case-Control Studies cervical squamous cell carcinoma Female Genetic Predisposition to Disease - genetics Genotype Humans Life Sciences & Biomedicine Medicine, Research & Experimental MicroRNAs - genetics Middle Aged miR-143/145 Polymorphism, Single Nucleotide qPCR Research & Experimental Medicine Risk Factors Science & Technology single-nucleotide polymorphism Uterine Cervical Neoplasms - genetics |
| title | Association between the rs3733846 in the flanking region of miR-143/145 and risk of cervical squamous cell carcinoma |
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