Association between the rs3733846 in the flanking region of miR-143/145 and risk of cervical squamous cell carcinoma

To investigate the effect of rs3733846 in the flanking region of miR-143/145 on susceptibility to cervical squamous cell carcinoma (CSCC). We collected venous blood samples from 242 CSCC patients and 250 healthy controls. The rs3733846 polymorphism was genotyped by SnaPshot and Sanger sequencing. The expression of miR-143/145 in CSCC tissues was detected by quantitative real-time PCR. The rs3733846 AG genotype was associated with a decreased risk of CSCC in genetic model (AGvs.AA: adjusted odds ratio [OR]: 0.44; 95% CI: 0.30–0.66; p < 0.001). Patients with the rs3733846 AG/GG genotypes had a reduced risk of developing poorly differential status (OR: 0.57; 95% CI: 0.33–0.98; p < 0.04) and lymph node metastasis (OR: 0.49; 95% CI: 0.26–0.92; p < 0.03). The rs3733846 in the flanking region of miR-143/145 was related to the susceptibility of CSCC.