Effect of a high fructose diet on metabolic parameters in carriers for hereditary fructose intolerance

Hyperuricemia is an independent risk factor for the metabolic syndrome and cardiovascular disease. We hypothesized that asymptomatic carriers for hereditary fructose intolerance (OMIM 22960) would have increased uric acid and altered component of the metabolic syndrome when exposed to fructose overfeeding. Six heterozygotes for HFI (hHFI) and 6 controls (Ctrl) were studied in a randomized, controlled, crossover trial. Participants ingested two identical test meals containing 0.7 g kg−1 glucose and 0.7 g kg−1 fructose according to a cross-over design, once after a 7-day on a low fructose diet (LoFruD,