Lung macrophages drive mucus production and steroid-resistant inflammation in chronic bronchitis

Background: Patients with chronic obstructive pulmonary disease (COPD) frequently suffer from chronic bronchitis (CB) and display steroid-resistant inflammation with increased sputum neutrophils and macrophages. Recently, a causal link between mucus hyper-concentration and disease progression of CB...

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Veröffentlicht in:	Respiratory research 2021-06, Vol.22 (1), p.1-172, Article 172
Hauptverfasser:	Andelid, Kristina, Ost, Karolina, Andersson, Anders, Mohamed, Esha, Jevnikar, Zala, Vanfleteren, Lowie E. G. W., Goransson, Melker
Format:	Artikel
Sprache:	eng
Schlagworte:	Activator protein 1 alpha Alveoli Antibodies Blood Bronchitis bronchoalveolar lavage Chronic bronchitis Chronic obstructive pulmonary disease Complications and side effects COPD Corticosteroids Crosstalk Cyclic AMP response element-binding protein Cytokines Development and progression Drug resistance Epithelial cells Epithelium equations function tests Genotype & phenotype goblet cell hyperplasia Health aspects Inflammation Leukocytes (neutrophilic) Life Sciences & Biomedicine Lipopolysaccharides Lung diseases Lung diseases, Obstructive Lungmedicin och allergi Macrophage-epithelial cross-talk Macrophages major mucin MUC5B Mucus Neutrophils Obstructive lung disease Pharmacology Phenotypes Physiological aspects reference values regression Respiratory Medicine and Allergy Respiratory System Science & Technology Sensitivity analysis Spirometry Sputum Sputum macrophages Steroid resistance Steroids Steroids (Drugs) therapy TNF tnf-alpha TNFα Transcription factors Tumor necrosis factor-α up-regulation Viscosity
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