The Role of miR-640: A Potential Suppressor in Breast Cancer via Wnt7b/β-catenin Signaling Pathway

In this study, we demonstrated that miR-640 is significantly downregulated in breast cancer (BC) tissues and cell lines. Overexpression of miR-640 inhibited the proliferation and migration of BC in vitro and in vivo, while depletion of miR-640 exhibited the opposite effect. Importantly, miR-640 coul...

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Veröffentlicht in:Frontiers in oncology 2021-04, Vol.11, p.645682-645682, Article 645682
Hauptverfasser: Tang, Chun, Wang, Xuehui, Ji, Changle, Zheng, Wenfang, Yu, Yunhe, Deng, Xiaochong, Zhou, Xiqian, Fang, Lin
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Sprache:eng
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Zusammenfassung:In this study, we demonstrated that miR-640 is significantly downregulated in breast cancer (BC) tissues and cell lines. Overexpression of miR-640 inhibited the proliferation and migration of BC in vitro and in vivo, while depletion of miR-640 exhibited the opposite effect. Importantly, miR-640 could directly target Wnt7b, thereby regulating Wnt/beta-catenin signaling pathway in BC. In conclusion, miR-640/Wnt7b suppresses BC cells tumorigenesis via Wnt/beta-catenin signaling pathway, which might be novel targets for BC targeted therapy.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2021.645682