Interaction between apigenin and sodium deoxycholate with raloxifene: A potential risk for clinical practice

•Apigenin and NaDC may affect the pharmacokinetics of raloxifene.•Apigenin and NaDC may affect hemostasis parameters in combination with raloxifene. Apigenin (API) and sodium deoxycholate (NaDC) have different pharmacodynamic properties and can affect pharmacokinetics of drugs without causing signif...

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Veröffentlicht in:European journal of pharmaceutical sciences 2021-06, Vol.161, p.105809, Article 105809
Hauptverfasser: Aleksandar, Rašković, Milica, Paut Kusturica, Gorana, Mitić, Boris, Milijašević, Anastazija, Stojšić-Milosavljević, Mladena, Lalić-Popović, Snežana, Stević, Nebojša, Stilinović, Slobodan, Gigov
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Sprache:eng
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Zusammenfassung:•Apigenin and NaDC may affect the pharmacokinetics of raloxifene.•Apigenin and NaDC may affect hemostasis parameters in combination with raloxifene. Apigenin (API) and sodium deoxycholate (NaDC) have different pharmacodynamic properties and can affect pharmacokinetics of drugs without causing significant toxicity. The aim of our study was to investigate the effect of API and NaDC on raloxifene pharmacokinetics in rats as well as on hemostasis parameters after applying the raloxifene therapeutic dose. Rats were treated daily with oral single dose of saline solution (1 ml/kg), API (10 mg/kg) and/or NaDC (4 mg/kg) for 7 days. Raloxifene was given orally or intravenously in a single dose (6 mg/kg) and during period of 24 h blood samples, feces and urine samples were collected. Blood samples were collected at the 15th, 30th, 45th, 60th, 90th minute and 2, 3, 4, 6, 8, 10, 12 and 24 h after raloxifene administration. Urine and feces samples were collected in the 3th, 6h, 12th and 24th hour of the experiment. Rats were divided into 10 groups each of which contained 6 animals. Differences were considered statistically significant if p
ISSN:0928-0987
1879-0720
DOI:10.1016/j.ejps.2021.105809