Obtainment of the spray-dried extracts of Peperomia pellucida L. (H.B.K.) using different atomization temperatures: physicochemical characterization and technological development for pharmaceutical applications

Spray-dried extracts are prepared as powders or granules after solvent removal, which can be obtained in the presence or absence of pharmaceutical adjuvants. This work aimed to optimize the process of obtaining dried extracts of Peperomia pellucida L. (HBK) by spray drying. The characterization of t...

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Veröffentlicht in:Daru 2021-04, Vol.29 (1), p.147-158
Hauptverfasser: da Silva, Rosali Maria Ferreira, Gomes, Thays Cristiane Barbosa Lucena, Campos, Adriana Fernandes, Vilela, Williana Tôrres, Silva, Pollyne Amorim, Sales, Victor de Albuquerque Wanderley, de Medeiros Schver, Giovanna Christinne Rocha, da Silva, Keyla Emmanuelle Ramos, Costa, Salvana Priscylla Manso, de Souza, Fábio Santos, de Freitas, Manolo Cleiton Costa, Arruda, Mara Sílvia Pinheiro, da Silva, Milton Nascimento, Rolim Neto, Pedro José
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Sprache:eng
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Zusammenfassung:Spray-dried extracts are prepared as powders or granules after solvent removal, which can be obtained in the presence or absence of pharmaceutical adjuvants. This work aimed to optimize the process of obtaining dried extracts of Peperomia pellucida L. (HBK) by spray drying. The characterization of the extract was performed by thermal analysis, specific surface area, particle size and high performance liquid chromatography (HPLC); then, capsules were developed for antimicrobial treatment, evaluating four bench lots by the determination of the angle of repose and time of flow, scanning electron microscopy, porosity and physicochemical quality control. There were no significant differences between the extracts obtained by spray drying at atomization temperatures of 140 °C, 160 °C and 180 °C, which was confirmed by thermal analysis. Specific surface area varied inversely with the mean particle size. Regarding the marker content by HPLC, no significant differences were found between the samples, although the flavonoid fraction was more stable at 160 °C. Bench lots (I to IV) were developed using the diluents Flowlac®, Starch® 1500, microcrystalline cellulose 250 and Cellactose® 80. Based on the results, the bench lot I, containing Flowlac®, was selected. The results of physicochemical quality control demonstrated that the selected formulation meets the pre-established parameters, and proving to be economically viable.
ISSN:2008-2231
1560-8115
2008-2231
DOI:10.1007/s40199-021-00393-w