Toward In Vivo Transdermal pH Sensing with a Validated Microneedle Membrane Electrode

We present herein the most complete characterization of microneedle (MN) potentiometric sensors for pH transdermal measurements for the time being. Initial in vitro assessment demonstrated suitable analytical performances (e.g., Nernstian slope, linear range of response from 8.5 to 5.0, and fast res...

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Veröffentlicht in:ACS sensors 2021-03, Vol.6 (3), p.1129-1137
Hauptverfasser: García-Guzmán, Juan José, Pérez-Ràfols, Clara, Cuartero, María, Crespo, Gastón A
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Sprache:eng
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Zusammenfassung:We present herein the most complete characterization of microneedle (MN) potentiometric sensors for pH transdermal measurements for the time being. Initial in vitro assessment demonstrated suitable analytical performances (e.g., Nernstian slope, linear range of response from 8.5 to 5.0, and fast response time) in both buffer media and artificial interstitial fluid (ISF). Excellent repeatability and reproducibility together with adequate selectivity and resiliency facilitate the appropriateness of the new pH MN sensor for transdermal ISF analysis in healthcare. The ability to resist skin insertions was evaluated in several ex vivo setups using three different animal skins (i.e., chicken, pork, and rat). The developed pH MN sensor was able to withstand from 5 to 10 repetitive insertions in all the skins considered with a minimal change in the calibration graph (
ISSN:2379-3694
2379-3694
DOI:10.1021/acssensors.0c02397