DNA methylation and breast cancer-associated variants

Background A breast cancer polygenic risk score (PRS) comprising 313 common variants reliably predicts disease risk. We examined possible relationships between genetic variation, regulation, and expression to clarify the molecular alterations associated with these variants. Methods Genome-wide methy...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Breast cancer research and treatment 2021-08, Vol.188 (3), p.713-727
Hauptverfasser:	Ho, Peh Joo, Dorajoo, Rajkumar, Ivanković, Ivna, Ong, Seeu Si, Khng, Alexis Jiaying, Tan, Benita Kiat-Tee, Tan, Veronique Kiak Mien, Lim, Swee Ho, Tan, Ern Yu, Tan, Su-Ming, Tan, Qing Ting, Yan, Zhiyan, Ngeow, Joanne, Sim, Yirong, Chan, Patrick, Chuan, Juliana Chen Jia, Chan, Ching Wan, Tang, Siau Wei, Hartman, Mikael, Li, Jingmei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Breast cancer Breast Neoplasms - epidemiology Breast Neoplasms - genetics Buffy coat Cancer Cancer research Child Children Deoxyribonucleic acid DNA DNA Methylation Epidemiology Female Gene frequency Gene mapping Genes Genetic aspects Genetic diversity Genome-Wide Association Study Genomes Genomics Genotypes Health aspects Humans Life Sciences & Biomedicine Medical colleges Medical research Medicine Medicine & Public Health Medicine, Experimental Methylation Middle Aged Multifactorial Inheritance Oncology Polygenic inheritance Polymorphism, Single Nucleotide Quantitative genetics Quantitative Trait Loci Science & Technology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Background A breast cancer polygenic risk score (PRS) comprising 313 common variants reliably predicts disease risk. We examined possible relationships between genetic variation, regulation, and expression to clarify the molecular alterations associated with these variants. Methods Genome-wide methylomic variation was quantified (MethylationEPIC) in Asian breast cancer patients (1152 buffy coats from peripheral whole blood). DNA methylation (DNAm) quantitative trait loci (mQTL) mapping was performed for 235 of the 313 variants with minor allele frequencies > 5%. Stability of identified mQTLs ( p
ISSN:	0167-6806 1573-7217
DOI:	10.1007/s10549-021-06185-9