Severe prolonged agitation due to intranasal naloxone overexposure

•Naloxone is generally safe, but can have severe adverse events if administered improperly.•Buprenorphine and benzodiazepines can be administered in cases of naloxone over administration, but may not be effective.•It is essential to provide appropriate instructions for administration of naloxone dur...

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Veröffentlicht in:	The American journal of emergency medicine 2021-04, Vol.42, p.261.e1-261.e2, Article 261
Hauptverfasser:	Brenner, Daniel S., Stolbach, Andrew I., Zschoche, Juliana, Bright, Leah
Format:	Artikel
Sprache:	eng
Schlagworte:	Abuse Administration, Intranasal Adult Adverse events Agitation Cardiac arrhythmia Cocaine Drug abuse Drug overdose Drug Overdose - psychology Drug withdrawal Emergency medical care Emergency medical services Emergency Medicine Female Humans Laboratories Life Sciences & Biomedicine Metabolites Naloxone Naloxone - therapeutic use Narcotic Antagonists - therapeutic use Narcotics Opioid Opioids Overdose Patients Psychomotor Agitation - etiology Science & Technology
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Beschreibung
Zusammenfassung:	•Naloxone is generally safe, but can have severe adverse events if administered improperly.•Buprenorphine and benzodiazepines can be administered in cases of naloxone over administration, but may not be effective.•It is essential to provide appropriate instructions for administration of naloxone during prescription to prevent misuse.
ISSN:	0735-6757 1532-8171
DOI:	10.1016/j.ajem.2020.08.069