Effect of Renal Dysfunction on Risk of Sudden Cardiac Death in Patients With Hypertrophic Cardiomyopathy

•Renal dysfunction had an incremental risk of future sudden death or potentially lethal arrhythmic events in patients with hypertrophic cardiomyopathy (HC).•Every 10 ml/min decline in the eGFR have a 24% increased risk of sudden death or potentially lethal arrhythmic events in HC patients.•An early risk stratification and active surveillance of the renal function may be favorable in the HC population. Renal dysfunction is a known risk of sudden cardiac death in patients with ischemic heart disease. However, the association between renal dysfunction and sudden death in hypertrophic cardiomyopathy (HC) patients remains unknown. This study investigated the significance of an impaired renal function for the sudden death risk in a cohort of patients with HC. We included 450 patients with HC (mean age 52.9 years, 65.1% men). The estimated glomerular filtration rate (eGFR) was evaluated at the time of the initial evaluation. Renal dysfunction was defined as an eGFR