Resting-state EEG alpha/theta ratio related to neuropsychological test performance in Parkinson’s Disease

•Parkinson’s related performance in the Judgment of Line Orientation Test is influenced by the right occipital α/θ.•A hemispheric approach of occipital α/θ must be considered for further research.•The right occipital α/θ is a promising marker for evaluating Parkinson’s Disease patients with visuospatial impairment. To determine possible associations of hemispheric-regional alpha/theta ratio (α/θ) with neuropsychological test performance in Parkinson’s Disease (PD) non-demented patients. 36 PD were matched to 36 Healthy Controls (HC). The α/θ in eight hemispheric regions was computed from the relative power spectral density of the resting-state quantitative electroencephalogram (qEEG). Correlations between α/θ and performance in several neuropsychological tests were conducted, significant findings were included in a moderation analysis. The α/θ in all regions was lower in PD than in HC, with larger effect sizes in the posterior regions. Right parietal, and right and left occipital α/θ had significant positive correlations with performance in Judgement of Line Orientation Test (JLOT) in PD. Adjusted moderation analysis indicated that right, but not left, occipital α/θ influenced the JLOT performance related to PD. Reduction of the occipital α/θ, in particular on the right side, was associated with visuospatial performance impairment in PD. Visuospatial impairment in PD, which is highly correlated with the subsequent development of dementia, is reflected in α/θ in the right posterior regions. The right occipital α/θ may represent a useful qEEG marker for evaluating the presence of early signs of cognitive decline in PD and the subsequent risk of dementia.