Regulation of Hepatic Metabolism and Cell Growth by the ATF/CREB Family of Transcription Factors

The liver is a major metabolic organ that regulates the whole-body metabolic homeostasis and controls hepatocyte proliferation and growth. The ATF/CREB family of transcription factors integrates nutritional and growth signals to the regulation of metabolism and cell growth in the liver, and deregula...

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Veröffentlicht in:Diabetes (New York, N.Y.) N.Y.), 2021-03, Vol.70 (3), p.653-664
Hauptverfasser: Cui, Aoyuan, Ding, Dong, Li, Yu
Format: Artikel
Sprache:eng
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Zusammenfassung:The liver is a major metabolic organ that regulates the whole-body metabolic homeostasis and controls hepatocyte proliferation and growth. The ATF/CREB family of transcription factors integrates nutritional and growth signals to the regulation of metabolism and cell growth in the liver, and deregulated ATF/CREB family signaling is implicated in the progression of type 2 diabetes, nonalcoholic fatty liver disease, and cancer. This article focuses on the roles of the ATF/CREB family in the regulation of glucose and lipid metabolism and cell growth and its importance in liver physiology. We also highlight how the disrupted ATF/CREB network contributes to human diseases and discuss the perspectives of therapeutically targeting ATF/CREB members in the clinic.
ISSN:0012-1797
1939-327X
DOI:10.2337/dbi20-0006