α-Particle-induced DNA damage tracks in peripheral blood mononuclear cells of [223Ra]RaCl2-treated prostate cancer patients

Purpose One therapy option for prostate cancer patients with bone metastases is the use of [ 223 Ra]RaCl 2 . The α-emitter 223 Ra creates DNA damage tracks along α-particle trajectories (α-tracks) in exposed cells that can be revealed by immunofluorescent staining of γ-H2AX+53BP1 DNA double-strand b...

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Veröffentlicht in:	European journal of nuclear medicine and molecular imaging 2021-08, Vol.48 (9), p.2761-2770
Hauptverfasser:	Schumann, S., Eberlein, U., Lapa, C., Müller, J., Serfling, S., Lassmann, M., Scherthan, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Blood Bone cancer Cardiology Damage Deoxyribonucleic acid DNA DNA damage Emitters Imaging Leukocytes (mononuclear) Life Sciences & Biomedicine Medicine Medicine & Public Health Metastases Nuclear Medicine Oncology Original Original Article Orthopedics Particle trajectories Patients Peripheral blood mononuclear cells Prostate cancer Radiation biology Radioisotopes Radiology Radiology, Nuclear Medicine & Medical Imaging Science & Technology
Online-Zugang:	Volltext
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