Decrease in serum calcitriol (but not free 25-hydroxyvitamin D) concentration in hip fracture healing

Decrease in serum calcitriol (but not free 25-hydroxyvitamin D) concentration in hip fracture healing

Objective To assess the decrease in serum calcitriol concentrations after hip fracture. Methods Serum concentrations of calcitriol, 25(OH)D, parathyroid hormone (PTH), directly measured free 25(OH)D, and indices of bone formation were measured in elderly patients with hip fracture (HF) and patients...

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Veröffentlicht in:Journal of endocrinological investigation 2021-09, Vol.44 (9), p.1847-1855
Hauptverfasser: Vaculik, J., Wenchich, L., Bobelyak, M., Pavelka, K., Stepan, J. J.
Format: Artikel
Sprache:eng
Schlagworte:
25-Hydroxyvitamin D
Aged
Aged, 80 and over
Arthroplasty, Replacement, Hip
Bone growth
Bone healing
Calcitriol
Calcitriol - blood
Endocrinology
Endocrinology & Metabolism
Female
Fracture Healing - physiology
Fractures
Hip
Hip Fractures - blood
Humans
Hyperparathyroidism
Internal Medicine
Life Sciences & Biomedicine
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Original Article
Osteogenesis
Parathyroid
Parathyroid hormone
Parathyroid Hormone - blood
Patients
Phosphates
Prospective Studies
Reference Values
Science & Technology
Vitamin D - analogs & derivatives
Vitamin D - blood
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Zusammenfassung:Objective To assess the decrease in serum calcitriol concentrations after hip fracture. Methods Serum concentrations of calcitriol, 25(OH)D, parathyroid hormone (PTH), directly measured free 25(OH)D, and indices of bone formation were measured in elderly patients with hip fracture (HF) and patients with elective hip replacement (EHR) at admission and after 7 weeks. Results A total of 45 patients with HF and 17 patients with EHR completed this prospective study. Baseline serum calcitriol levels were ≤ 60 pmol/l in 26% of the HF patients. After 7 weeks, they significantly decreased ( p  
ISSN:0391-4097
1720-8386
1720-8386
DOI:10.1007/s40618-020-01489-x