Pre-HCT mosaicism increases relapse risk and lowers survival in acute lymphoblastic leukemia patients post–unrelated HCT

•Pre-HCT mosaicism is related to increased relapse risk and lower survival after unrelated HCT, independent of cytogenetics at diagnosis.•Pre-HCT mosaicism could be a useful clinical tool to guide risk stratification in acute lymphoblastic leukemia patients. [Display omitted]

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Bibliographische Detailangaben
Veröffentlicht in:	Blood advances 2021-01, Vol.5 (1), p.66-70
Hauptverfasser:	Wang, Yiwen, Zhou, Weiyin, Wang, Junke, Karaesmen, Ezgi, Tang, Hancong, McCarthy, Philip L., Pasquini, Marcelo C., Wang, Youjin, McReynolds, Lisa J., Katki, Hormuzd A., Machiela, Mitchell J., Yeager, Meredith, Pooler, Loreall, Sheng, Xin, Haiman, Christopher A., Van Den Berg, David, Spellman, Stephen R., Wang, Tao, Kuxhausen, Michelle, Chanock, Stephen J., Lee, Stephanie J., Clay-Gilmour, Alyssa I., Hahn, Theresa E., Gadalla, Shahinaz M., Sucheston-Campbell, Lara E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Hematology Humans Life Sciences & Biomedicine Mosaicism Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Recurrence Science & Technology Stimulus Report Transplantation, Homologous
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	•Pre-HCT mosaicism is related to increased relapse risk and lower survival after unrelated HCT, independent of cytogenetics at diagnosis.•Pre-HCT mosaicism could be a useful clinical tool to guide risk stratification in acute lymphoblastic leukemia patients. [Display omitted]
ISSN:	2473-9529 2473-9537
DOI:	10.1182/bloodadvances.2020003366