A novel dispersive liquid-liquid microextraction using a low density deep eutectic solvent-gas chromatography tandem mass spectrometry for the determination of polycyclic aromatic hydrocarbons in soft drinks
•A new eco-friendly hydrophobic deep eutectic solvent (DES) was synthesized•DES (hexanoic acid and camphor) showed a good extraction yield towards 15 PHAs•A LDDES-DLLME - GC-MS/MS method was successfully optimized and validated•Total PAHs levels in tea beverage ranged from 0.20 µg.L-1 to 1.82 µg.L-1...
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| Veröffentlicht in: | JOURNAL OF CHROMATOGRAPHY A 2021-01, Vol.1635, p.461736, Article 461736 |
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| container_title | JOURNAL OF CHROMATOGRAPHY A |
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| creator | Caldeirão, Lucas Fernandes, José O. Gonzalez, Mario Henrique Godoy, Helena Teixeira Cunha, Sara C. |
| description | •A new eco-friendly hydrophobic deep eutectic solvent (DES) was synthesized•DES (hexanoic acid and camphor) showed a good extraction yield towards 15 PHAs•A LDDES-DLLME - GC-MS/MS method was successfully optimized and validated•Total PAHs levels in tea beverage ranged from 0.20 µg.L-1 to 1.82 µg.L-1
Ready-to-drink teas can provide, if properly packaged, the taste and wellness character of traditional teas. Nevertheless, in tea processing, there may be several contaminations, among which polycyclic aromatic hydrocarbons (PAHs), anthropogenic contaminants that can present carcinogenic and mutagenic properties. In this work, a novel low-density deep eutectic solvent-based dispersive liquid-liquid microextraction (LDDES-DLLME) procedure followed by gas chromatography tandem mass spectrometry (GC-MS/MS) was optimized for analysis of 15 polycyclic aromatic hydrocarbons (PAHs) in ready-to-drink herbal-based beverages. The new deep eutectic solvent (DES) was synthesized with natural compounds (camphor and hexanoic acid). Several parameters of the extraction procedure such as type and volume of extraction solvent, type, volume of dispersive solvent, and time of extraction were evaluated to achieve the highest yield and to attain the lowest detection limits. The validated method showed very low limits of detection (0.01 μg L−1) and quantification (0.2 μg L−1), good inter- and intra-day precisions (RSD |
| doi_str_mv | 10.1016/j.chroma.2020.461736 |
| format | Article |
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Ready-to-drink teas can provide, if properly packaged, the taste and wellness character of traditional teas. Nevertheless, in tea processing, there may be several contaminations, among which polycyclic aromatic hydrocarbons (PAHs), anthropogenic contaminants that can present carcinogenic and mutagenic properties. In this work, a novel low-density deep eutectic solvent-based dispersive liquid-liquid microextraction (LDDES-DLLME) procedure followed by gas chromatography tandem mass spectrometry (GC-MS/MS) was optimized for analysis of 15 polycyclic aromatic hydrocarbons (PAHs) in ready-to-drink herbal-based beverages. The new deep eutectic solvent (DES) was synthesized with natural compounds (camphor and hexanoic acid). Several parameters of the extraction procedure such as type and volume of extraction solvent, type, volume of dispersive solvent, and time of extraction were evaluated to achieve the highest yield and to attain the lowest detection limits. The validated method showed very low limits of detection (0.01 μg L−1) and quantification (0.2 μg L−1), good inter- and intra-day precisions (RSD<16.87%), and recoveries higher than 69%. The method was applied to 16 type of samples and it was found total PAHs levels ranging from 0.20 to 1.82 μg L−1. The developed LDDES-DLLME showed a reliable and innovative alternative for the extraction of PAHs from beverages, cost-effective and environmentally friendly, and providing a satisfactory throughput.</description><identifier>ISSN: 0021-9673</identifier><identifier>EISSN: 1873-3778</identifier><identifier>DOI: 10.1016/j.chroma.2020.461736</identifier><identifier>PMID: 33254001</identifier><language>eng</language><publisher>AMSTERDAM: Elsevier B.V</publisher><subject>Biochemical Research Methods ; Biochemistry & Molecular Biology ; Carbonated Beverages - analysis ; Chemistry ; Chemistry, Analytical ; Environmentally friendly ; Food Analysis - methods ; Food contaminant ; Gas Chromatography-Mass Spectrometry ; Green chemistry ; Life Sciences & Biomedicine ; Limit of Detection ; Liquid Phase Microextraction - methods ; Miniaturized techniques ; Physical Sciences ; Polycyclic Aromatic Hydrocarbons - analysis ; Science & Technology ; Tea ; Water Pollutants, Chemical - analysis</subject><ispartof>JOURNAL OF CHROMATOGRAPHY A, 2021-01, Vol.1635, p.461736, Article 461736</ispartof><rights>2020</rights><rights>Copyright © 2020. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>27</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000603564600018</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c362t-8d4c610f674868193cc424b73ff3c69c7fab43003dc15f5b53593e613357b2f13</citedby><cites>FETCH-LOGICAL-c362t-8d4c610f674868193cc424b73ff3c69c7fab43003dc15f5b53593e613357b2f13</cites><orcidid>0000-0002-0139-2742 ; 0000-0003-2810-3282 ; 0000-0002-8565-2942 ; 0000-0003-4320-2318</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.chroma.2020.461736$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,39263,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33254001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caldeirão, Lucas</creatorcontrib><creatorcontrib>Fernandes, José O.</creatorcontrib><creatorcontrib>Gonzalez, Mario Henrique</creatorcontrib><creatorcontrib>Godoy, Helena Teixeira</creatorcontrib><creatorcontrib>Cunha, Sara C.</creatorcontrib><title>A novel dispersive liquid-liquid microextraction using a low density deep eutectic solvent-gas chromatography tandem mass spectrometry for the determination of polycyclic aromatic hydrocarbons in soft drinks</title><title>JOURNAL OF CHROMATOGRAPHY A</title><addtitle>J CHROMATOGR A</addtitle><addtitle>J Chromatogr A</addtitle><description>•A new eco-friendly hydrophobic deep eutectic solvent (DES) was synthesized•DES (hexanoic acid and camphor) showed a good extraction yield towards 15 PHAs•A LDDES-DLLME - GC-MS/MS method was successfully optimized and validated•Total PAHs levels in tea beverage ranged from 0.20 µg.L-1 to 1.82 µg.L-1
Ready-to-drink teas can provide, if properly packaged, the taste and wellness character of traditional teas. Nevertheless, in tea processing, there may be several contaminations, among which polycyclic aromatic hydrocarbons (PAHs), anthropogenic contaminants that can present carcinogenic and mutagenic properties. In this work, a novel low-density deep eutectic solvent-based dispersive liquid-liquid microextraction (LDDES-DLLME) procedure followed by gas chromatography tandem mass spectrometry (GC-MS/MS) was optimized for analysis of 15 polycyclic aromatic hydrocarbons (PAHs) in ready-to-drink herbal-based beverages. The new deep eutectic solvent (DES) was synthesized with natural compounds (camphor and hexanoic acid). Several parameters of the extraction procedure such as type and volume of extraction solvent, type, volume of dispersive solvent, and time of extraction were evaluated to achieve the highest yield and to attain the lowest detection limits. The validated method showed very low limits of detection (0.01 μg L−1) and quantification (0.2 μg L−1), good inter- and intra-day precisions (RSD<16.87%), and recoveries higher than 69%. The method was applied to 16 type of samples and it was found total PAHs levels ranging from 0.20 to 1.82 μg L−1. The developed LDDES-DLLME showed a reliable and innovative alternative for the extraction of PAHs from beverages, cost-effective and environmentally friendly, and providing a satisfactory throughput.</description><subject>Biochemical Research Methods</subject><subject>Biochemistry & Molecular Biology</subject><subject>Carbonated Beverages - analysis</subject><subject>Chemistry</subject><subject>Chemistry, Analytical</subject><subject>Environmentally friendly</subject><subject>Food Analysis - methods</subject><subject>Food contaminant</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Green chemistry</subject><subject>Life Sciences & Biomedicine</subject><subject>Limit of Detection</subject><subject>Liquid Phase Microextraction - methods</subject><subject>Miniaturized techniques</subject><subject>Physical Sciences</subject><subject>Polycyclic Aromatic Hydrocarbons - analysis</subject><subject>Science & Technology</subject><subject>Tea</subject><subject>Water Pollutants, Chemical - analysis</subject><issn>0021-9673</issn><issn>1873-3778</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNUc2O0zAQthCILQtvgJDvKMWOHTu9IK0q_qSVuMA5cuxx65LYwXa65Cl5JbzNskfEacby9zMzH0KvKdlSQsW701YfYxjVtiY12XJBJRNP0Ia2klVMyvYp2hBS02onJLtCL1I6EUIlkfVzdMVY3fDy3KDfN9iHMwzYuDRBTO4MeHA_Z2eqteDR6RjgV45KZxc8npPzB6zwEO6wAZ9cXkqFCcOcoUA0TmE4g8_VQSW8zpjDIarpuOCsvIERjyolXPx0Lr-Q44JtiDgfoShliKPz6uIVLJ7CsOhFD0VXXaRKc1xMDFrFPviEnS-GNmMTnf-RXqJnVg0JXj3Ua_T944dv-8_V7ddPX_Y3t5Vmos5Va7gWlFgheStaumNa85r3klnLtNhpaVXPGSHMaNrYpm9Ys2MgKGON7GtL2TXiq245TkoRbDdFN6q4dJR09_l0p27dvbvPp1vzKbQ3K22a-xHMI-lvIAXQroA76INN2oHX8AgjhAjCGsFF6Wi7d_lyp32YfS7Ut_9PLej3KxrKlc4OYvfAMC6WXDoT3L9X-QP6-8rj</recordid><startdate>20210104</startdate><enddate>20210104</enddate><creator>Caldeirão, Lucas</creator><creator>Fernandes, José O.</creator><creator>Gonzalez, Mario Henrique</creator><creator>Godoy, Helena Teixeira</creator><creator>Cunha, Sara C.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-0139-2742</orcidid><orcidid>https://orcid.org/0000-0003-2810-3282</orcidid><orcidid>https://orcid.org/0000-0002-8565-2942</orcidid><orcidid>https://orcid.org/0000-0003-4320-2318</orcidid></search><sort><creationdate>20210104</creationdate><title>A novel dispersive liquid-liquid microextraction using a low density deep eutectic solvent-gas chromatography tandem mass spectrometry for the determination of polycyclic aromatic hydrocarbons in soft drinks</title><author>Caldeirão, Lucas ; Fernandes, José O. ; Gonzalez, Mario Henrique ; Godoy, Helena Teixeira ; Cunha, Sara C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-8d4c610f674868193cc424b73ff3c69c7fab43003dc15f5b53593e613357b2f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biochemical Research Methods</topic><topic>Biochemistry & Molecular Biology</topic><topic>Carbonated Beverages - analysis</topic><topic>Chemistry</topic><topic>Chemistry, Analytical</topic><topic>Environmentally friendly</topic><topic>Food Analysis - methods</topic><topic>Food contaminant</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>Green chemistry</topic><topic>Life Sciences & Biomedicine</topic><topic>Limit of Detection</topic><topic>Liquid Phase Microextraction - methods</topic><topic>Miniaturized techniques</topic><topic>Physical Sciences</topic><topic>Polycyclic Aromatic Hydrocarbons - analysis</topic><topic>Science & Technology</topic><topic>Tea</topic><topic>Water Pollutants, Chemical - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caldeirão, Lucas</creatorcontrib><creatorcontrib>Fernandes, José O.</creatorcontrib><creatorcontrib>Gonzalez, Mario Henrique</creatorcontrib><creatorcontrib>Godoy, Helena Teixeira</creatorcontrib><creatorcontrib>Cunha, Sara C.</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>JOURNAL OF CHROMATOGRAPHY A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caldeirão, Lucas</au><au>Fernandes, José O.</au><au>Gonzalez, Mario Henrique</au><au>Godoy, Helena Teixeira</au><au>Cunha, Sara C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel dispersive liquid-liquid microextraction using a low density deep eutectic solvent-gas chromatography tandem mass spectrometry for the determination of polycyclic aromatic hydrocarbons in soft drinks</atitle><jtitle>JOURNAL OF CHROMATOGRAPHY A</jtitle><stitle>J CHROMATOGR A</stitle><addtitle>J Chromatogr A</addtitle><date>2021-01-04</date><risdate>2021</risdate><volume>1635</volume><spage>461736</spage><pages>461736-</pages><artnum>461736</artnum><issn>0021-9673</issn><eissn>1873-3778</eissn><abstract>•A new eco-friendly hydrophobic deep eutectic solvent (DES) was synthesized•DES (hexanoic acid and camphor) showed a good extraction yield towards 15 PHAs•A LDDES-DLLME - GC-MS/MS method was successfully optimized and validated•Total PAHs levels in tea beverage ranged from 0.20 µg.L-1 to 1.82 µg.L-1
Ready-to-drink teas can provide, if properly packaged, the taste and wellness character of traditional teas. Nevertheless, in tea processing, there may be several contaminations, among which polycyclic aromatic hydrocarbons (PAHs), anthropogenic contaminants that can present carcinogenic and mutagenic properties. In this work, a novel low-density deep eutectic solvent-based dispersive liquid-liquid microextraction (LDDES-DLLME) procedure followed by gas chromatography tandem mass spectrometry (GC-MS/MS) was optimized for analysis of 15 polycyclic aromatic hydrocarbons (PAHs) in ready-to-drink herbal-based beverages. The new deep eutectic solvent (DES) was synthesized with natural compounds (camphor and hexanoic acid). Several parameters of the extraction procedure such as type and volume of extraction solvent, type, volume of dispersive solvent, and time of extraction were evaluated to achieve the highest yield and to attain the lowest detection limits. The validated method showed very low limits of detection (0.01 μg L−1) and quantification (0.2 μg L−1), good inter- and intra-day precisions (RSD<16.87%), and recoveries higher than 69%. The method was applied to 16 type of samples and it was found total PAHs levels ranging from 0.20 to 1.82 μg L−1. The developed LDDES-DLLME showed a reliable and innovative alternative for the extraction of PAHs from beverages, cost-effective and environmentally friendly, and providing a satisfactory throughput.</abstract><cop>AMSTERDAM</cop><pub>Elsevier B.V</pub><pmid>33254001</pmid><doi>10.1016/j.chroma.2020.461736</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-0139-2742</orcidid><orcidid>https://orcid.org/0000-0003-2810-3282</orcidid><orcidid>https://orcid.org/0000-0002-8565-2942</orcidid><orcidid>https://orcid.org/0000-0003-4320-2318</orcidid></addata></record> |
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| subjects | Biochemical Research Methods Biochemistry & Molecular Biology Carbonated Beverages - analysis Chemistry Chemistry, Analytical Environmentally friendly Food Analysis - methods Food contaminant Gas Chromatography-Mass Spectrometry Green chemistry Life Sciences & Biomedicine Limit of Detection Liquid Phase Microextraction - methods Miniaturized techniques Physical Sciences Polycyclic Aromatic Hydrocarbons - analysis Science & Technology Tea Water Pollutants, Chemical - analysis |
| title | A novel dispersive liquid-liquid microextraction using a low density deep eutectic solvent-gas chromatography tandem mass spectrometry for the determination of polycyclic aromatic hydrocarbons in soft drinks |
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