Rhodium-catalyzed direct C-H amination of 2-arylindoles and 7-arylindoles with free amines

Rhodium-catalyzed direct C-H amination of 2-arylindoles and 7-arylindoles with free amines

Synthetically meaningful 2-(2'-amino)phenylindoles or 7-(2'-amino)phenylindoles were accessed by rhodium-catalyzed NH-indole-directed C-H amination of 2-aryl-1H-indoles or 7-aryl-1H-indoles with free amines. This method is compatible with a wide variety of functional groups, thus enabling...

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Veröffentlicht in:Tetrahedron letters 2021-01, Vol.62, p.152686, Article 152686
Hauptverfasser: Qin, Yao, Zhuang, Weihui, Guo, Xiemin, Zhang, Xiaofeng, Huang, Qiufeng
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Zusammenfassung:Synthetically meaningful 2-(2'-amino)phenylindoles or 7-(2'-amino)phenylindoles were accessed by rhodium-catalyzed NH-indole-directed C-H amination of 2-aryl-1H-indoles or 7-aryl-1H-indoles with free amines. This method is compatible with a wide variety of functional groups, thus enabling expedient access to fused-polycyclic frameworks containing indole units. (C) 2020 Elsevier Ltd. All rights reserved.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2020.152686