Anti-Angiogenic Properties of Ginsenoside Rg3

Ginsenoside Rg3 (Rg3) is a member of the ginsenoside family of chemicals extracted from Panax ginseng. Like other ginsenosides, Rg3 has two epimers: 20(S)-ginsenoside Rg3 (SRg3) and 20(R)-ginsenoside Rg3 (RRg3). Rg3 is an intriguing molecule due to its anti-cancer properties. One facet of the anti-c...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2020-10, Vol.25 (21), p.4905, Article 4905
Hauptverfasser:	Nakhjavani, Maryam, Smith, Eric, Townsend, Amanda R., Price, Timothy J., Hardingham, Jennifer E.
Format:	Artikel
Sprache:	eng
Schlagworte:	20(R)-ginsenoside Rg3 20(S)-ginsenoside Rg3 Angiogenesis Angiogenesis Inhibitors - metabolism Angiogenesis Inhibitors - pharmacology Animals Antiangiogenics Binding sites Biochemistry & Molecular Biology Cancer Cell cycle Chemistry Chemistry, Multidisciplinary epimer Ginseng ginsenoside Rg3 Ginsenosides Ginsenosides - metabolism Ginsenosides - pharmacology Hemoglobin Humans Kinases Life Sciences & Biomedicine Ligands Neovascularization, Physiologic - drug effects Phosphorylation Physical Sciences Prodrugs - metabolism Review Science & Technology Vascular endothelial growth factor
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Zusammenfassung:	Ginsenoside Rg3 (Rg3) is a member of the ginsenoside family of chemicals extracted from Panax ginseng. Like other ginsenosides, Rg3 has two epimers: 20(S)-ginsenoside Rg3 (SRg3) and 20(R)-ginsenoside Rg3 (RRg3). Rg3 is an intriguing molecule due to its anti-cancer properties. One facet of the anti-cancer properties of Rg3 is the anti-angiogenic action. This review describes the controversies on the effects and effective dose range of Rg3, summarizes the evidence on the efficacy of Rg3 on angiogenesis, and raises the possibility that Rg3 is a prodrug.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules25214905