Metal-Free Electrochemical Oxidative Dihalogenation of Quinolines on the C5 and C7 Positions UsingN-Halosuccinimides

An efficient and convenient method for electrochemically oxidative dichlorination or dibromination of 8-aminoquinolines on C5 and C7 positions usingN-halosuccinimides (NCS and NBS) as the halogen source was described. Substrates with various functional groups were transformed smoothly and the halogenated products were obtained in good to excellent yields. These transformations feature transition-metal-free, oxidant-free, and short reaction time.