Indole-3-carbaldehydes Arylhydrazones as Multisite C-Nucleophiles in the Reactions with Quinazoline

C,C-Coupling of indole-3-carbaldehyde arylhydrazones with quinazoline in trifluoroacetic acid has occurred at position 5 or 7′ of the hydrazone molecule and has afforded the σ-adducts. The C,C-coupling has been accompanied by a change in the E -configuration of the C=N bond of the starting hydrazone...

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Veröffentlicht in:	Russian journal of general chemistry 2020-09, Vol.90 (9), p.1601-1610
Hauptverfasser:	Azev, Yu. A., Koptyaeva, O. S., Eltsov, O. S., Yakovleva, Yu. A., Tsmokalyuk, A. N., Ivoilova, A. V., Seliverstova, E. A., Pospelova, T. A., Bakulev, V. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adducts Antiviral agents Chemistry Chemistry and Materials Science Chemistry, Multidisciplinary Chemistry/Food Science Configurations Coupling Hydrazides Hydrazones Nucleophiles Physical Sciences Science & Technology
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Beschreibung
Zusammenfassung:	C,C-Coupling of indole-3-carbaldehyde arylhydrazones with quinazoline in trifluoroacetic acid has occurred at position 5 or 7′ of the hydrazone molecule and has afforded the σ-adducts. The C,C-coupling has been accompanied by a change in the E -configuration of the C=N bond of the starting hydrazones to the Z -configuration in the formed quinazoline trifluoroacetyl hydrazides.
ISSN:	1070-3632 1608-3350
DOI:	10.1134/S1070363220090030