Iriomoteolides-14a and 14b, New Cytotoxic 15-Membered Macrolides from Marine Dinoflagellate Amphidinium Species

Two new macrolides, iriomoteolides-14a (1) and 14b (2) have been isolated from the marine dinoflagellate Amphidinium species (strain KCA09057). Compounds 1 and 2 are 15-membered macrolides, which are structural analogs of amphidinolides O (3) and P (4). The structures of 1 and 2 were assigned on the...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2020/09/01, Vol.68(9), pp.864-867
Hauptverfasser:	Tsuda, Masashi, Makihara, Ryui, Tsuda, Masayuki, Suzuki, Takeyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Amphidinium Antibiotics Chemical compounds Chemistry Chemistry, Medicinal Chemistry, Multidisciplinary Cytotoxicity dinoflagellate Dinoflagellates Dinoflagellida - chemistry Dinoflagellida - classification Life Sciences & Biomedicine macrolide Macrolides - chemistry Microorganisms Molecular Structure NMR Nuclear magnetic resonance Pharmacology & Pharmacy Physical Sciences Science & Technology
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Zusammenfassung:	Two new macrolides, iriomoteolides-14a (1) and 14b (2) have been isolated from the marine dinoflagellate Amphidinium species (strain KCA09057). Compounds 1 and 2 are 15-membered macrolides, which are structural analogs of amphidinolides O (3) and P (4). The structures of 1 and 2 were assigned on the basis of detailed NMR analyses and chemical conversion studies. Compounds 1 and 2 showed moderate cytotoxic activity against human cervix adenocarcinoma HeLa cells.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.c20-00329