Synthesis of novel spiro-pyrazole and spiro-isoxazoline derivatives of 9α- and 9β-hydroxyparthenolide

[Display omitted] •9α and 9β-hydroxyparthenolide were isolated from Anvillea radiata.•Diastereoselective synthesis of novel spiropyrazoles and spiroisoxazolines.•Synthesis of α,β- unsaturated novel ketones as Michael receptor. A series of novel spiropyrazoles and spiroisoxazolines was efficiently synthesized. Structural modifications were performed at the C-9 and C-13 positions of 9α- and 9β-hydroxyparthenolide, which were isolated from the aerial parts of Anvillea radiata. The structures and stereochemistry of the cycloadducts were fully established by spectroscopic methods including X-ray diffraction data.