CD32 is enriched on CD4(dim)CD8(bright)T cells

CD4(dim)CD8(bright)T cells, a genuine population of CD8(+)T cells, are highly activated and cytolytic. Recently, the low affinity IgG Fc fragment receptor CD32a was described as marker of HIV latency while others reported that CD32a is associated with T cell activation. Given that we have previously established that CD4(dim)CD8(bright)T cells are highly activated, mediate anti-HIV responses, and are infected by HIV, we assessed here CD32 expression on CD4(dim)CD8(bright)T cells in context of HIV. CD32 frequency on peripheral CD4(dim)CD8(bright)and CD4(+)T cells was determined by flow cytometry among HIV negative and HIV positive patients. We report that among HIV(-)individuals, mean CD32 percent expression was 60% on CD4(dim)CD8(bright)T cells and 17% on CD4(+)T cells (p