Antibacterial synergy between linezolid and baicalein against methicillin-resistant Staphylococcus aureus biofilm in vivo

Antibacterial synergy between linezolid and baicalein against methicillin-resistant Staphylococcus aureus biofilm in vivo

Methicillin-resistant Staphylococcus aureus (MRSA) can form biofilms, which prevents the penetration of antibiotics, decreasing their efficacy. This study investigated whether baicalein has synergistic antibacterial effects with linezolid in vivo. We cultivated MRSA 17546 biofilms on silicone implan...

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Veröffentlicht in:Microbial pathogenesis 2020-10, Vol.147, p.104411-104411, Article 104411
Hauptverfasser: Liu, Tangjuan, Luo, Jing, Bi, Guan, Du, Zhongye, Kong, Jinliang, Chen, Yiqiang
Format: Artikel
Sprache:eng
Schlagworte:
Antibacterial synergy
Baicalein
Biofilm infection
Immunology
In vivo
Life Sciences & Biomedicine
Linezolid
Methicillin-resistant Staphylococcus aureus (MRSA)
Microbiology
Science & Technology
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Zusammenfassung:Methicillin-resistant Staphylococcus aureus (MRSA) can form biofilms, which prevents the penetration of antibiotics, decreasing their efficacy. This study investigated whether baicalein has synergistic antibacterial effects with linezolid in vivo. We cultivated MRSA 17546 biofilms on silicone implants and inserted them into the air pouches of rat models. The rats were treated with linezolid, baicalein, or a combination therapy for three consecutive days. All treatments reduced the number of colony-forming units (CFU) in the biofilms compared to the control (p 
ISSN:0882-4010
1096-1208
DOI:10.1016/j.micpath.2020.104411