Effect of fiberoptic bronchoscope combined with ambroxol alveolar lavage on the treatment of pulmonary atelectasis in severe pneumonia and its influences on systemic inflammatory response and respiratory mechanics

Objective: To explore the efficacy of fiberoptic bronchoscope combined with ambroxol alveolar lavage on patients with both severe pneumonia and pulmonary atelectasis and its effects on their systemic inflammatory response and respiratory mechanical indexes. Methods: A total of 60 patients diagnosed with both severe pneumonia and pulmonary atelectasis from May 2018 to May 2019 were enrolled and studied, and they were randomly assigned to a control group and an observation group (each n=30). The control group was treated with fiberoptic bronchoscopic lavage, while the observation group was treated with fiberoptic bronchoscope combined with ambroxol alveolar lavage. After 2 weeks of intervention, the efficacy and complications were compared between the two groups, and the following aspects of the two groups before and after treatment and at 6-month follow-up were analyzed: Serum inflammatory indexes including C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) and respiratory mechanical indexes including forced expiratory volume in 1 second (FEV1)% and FEV1/forced vital capacity (FVC), arterial oxygen partial pressure (PaO2), arterial partial pressure of carbon dioxide (PCO2), and oxygen saturation. Results: The total effective rate of the observation group was significantly higher than that of the control group (P