Bioptic intraprostatic chronic inflammation predicts adverse pathology at radical prostatectomy in patients with low-grade prostate cancer

•Irani score provide a readily-available assessment of inflammation aggressiveness and extent in hematoxylin eosin stained prostate biopsy cores.•Prostatic inflammation is inversely correlated with presence and aggressiveness of prostate cancer.•Low-grade inflammation in prostate biopsy cores is an independent predictor of adverse pathology at radical prostatectomy. To determine the potential role of bioptic inflammation (Irani score) in predicting adverse pathology (AP) at radical prostatectomy (RP) in patients with low-grade (ISUP Gleason Group [ISUP GG] 1 and 2) prostate cancer (CaP). After institutional review board-approval, we identified patients who underwent prostate biopsy, had bioptic Irani score assessment, were diagnosed with low-grade CaP (ISUP GG 1–2, prostate-specific antigen [PSA]