CONCISE SYNTHESIS OF TPCA-1 AND RELATED THIOPHENE-CARBOXAMIDES BY CROSS COUPLING

CONCISE SYNTHESIS OF TPCA-1 AND RELATED THIOPHENE-CARBOXAMIDES BY CROSS COUPLING

A synthesis of 5-substituted 2-[(aminocarbonyeamino]-3-thiophene-carboxamides is described. The coupling reaction of 2-ureidothiophene-3-carboxamide and various aryl compounds allows the concise approach of promising candidates for IKK-2 inhibitor, such as TPCA-1.

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Veröffentlicht in:Heterocycles 2020-01, Vol.101 (2), p.707-716
Hauptverfasser: Kawasaki, Norihiko, Fukuda, Hayato, Ishihara, Jun
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Zusammenfassung:A synthesis of 5-substituted 2-[(aminocarbonyeamino]-3-thiophene-carboxamides is described. The coupling reaction of 2-ureidothiophene-3-carboxamide and various aryl compounds allows the concise approach of promising candidates for IKK-2 inhibitor, such as TPCA-1.
ISSN:0385-5414
1881-0942
DOI:10.3987/COM-19-S(F)43