Interleukin-6 in Rheumatoid Arthritis

The role of interleukin (IL)-6 in health and disease has been under a lot of scrutiny in recent years, particularly during the recent COVID-19 pandemic. The inflammatory pathways in which IL-6 is involved are also partly responsible of the development and progression of rheumatoid arthritis (RA), op...

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Veröffentlicht in:International journal of molecular sciences 2020-07, Vol.21 (15), p.5238, Article 5238
Hauptverfasser: Pandolfi, Franco, Franza, Laura, Carusi, Valentina, Altamura, Simona, Andriollo, Gloria, Nucera, Eleonora
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Sprache:eng
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Zusammenfassung:The role of interleukin (IL)-6 in health and disease has been under a lot of scrutiny in recent years, particularly during the recent COVID-19 pandemic. The inflammatory pathways in which IL-6 is involved are also partly responsible of the development and progression of rheumatoid arthritis (RA), opening interesting perspectives in terms of therapy. Anti-IL-6 drugs are being used with variable degrees of success in other diseases and are being tested in RA. Results have been encouraging, particularly when anti-IL-6 has been used with other drugs, such as metothrexate (MTX). In this review we discuss the main immunologic aspects that make anti-IL-6 a good candidate in RA, but despite the main therapeutic options available to target IL-6, no gold standard treatment has been established so far.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21155238