In vivo demonstration of selective vulnerability of dopamine neurons
•Nigral dopamine neuron is highly energy-consuming and vulnerable to stress.•Parkinsonism due to Kernohan notch rarely studied with functional imaging.•Loss of dopamine transporter uptake and preserved metabolism in striatum and midbrain.•Discrepancy between dopamine uptake and metabolism suggests s...
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| Veröffentlicht in: | Journal of the neurological sciences 2020-08, Vol.415, p.116946-116946, Article 116946 |
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| container_end_page | 116946 |
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| container_start_page | 116946 |
| container_title | Journal of the neurological sciences |
| container_volume | 415 |
| creator | Yoo, Dallah Kim, Hyug-Gi Bang, Ji-In Lee, Kyung Mi Ahn, Tae-Beom |
| description | •Nigral dopamine neuron is highly energy-consuming and vulnerable to stress.•Parkinsonism due to Kernohan notch rarely studied with functional imaging.•Loss of dopamine transporter uptake and preserved metabolism in striatum and midbrain.•Discrepancy between dopamine uptake and metabolism suggests selective vulnerability. |
| doi_str_mv | 10.1016/j.jns.2020.116946 |
| format | Article |
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| ispartof | Journal of the neurological sciences, 2020-08, Vol.415, p.116946-116946, Article 116946 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /> |
| subjects | Clinical Neurology Dopamine Dopamine neurons Dopamine Plasma Membrane Transport Proteins Dopaminergic Neurons Humans Kernohan notch Life Sciences & Biomedicine Neurosciences Neurosciences & Neurology Parkinsonism Positron emission tomography Science & Technology Vulnerability |
| title | In vivo demonstration of selective vulnerability of dopamine neurons |
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