In vivo demonstration of selective vulnerability of dopamine neurons

•Nigral dopamine neuron is highly energy-consuming and vulnerable to stress.•Parkinsonism due to Kernohan notch rarely studied with functional imaging.•Loss of dopamine transporter uptake and preserved metabolism in striatum and midbrain.•Discrepancy between dopamine uptake and metabolism suggests s...

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Veröffentlicht in:	Journal of the neurological sciences 2020-08, Vol.415, p.116946-116946, Article 116946
Hauptverfasser:	Yoo, Dallah, Kim, Hyug-Gi, Bang, Ji-In, Lee, Kyung Mi, Ahn, Tae-Beom
Format:	Artikel
Sprache:	eng
Schlagworte:	Clinical Neurology Dopamine Dopamine neurons Dopamine Plasma Membrane Transport Proteins Dopaminergic Neurons Humans Kernohan notch Life Sciences & Biomedicine Neurosciences Neurosciences & Neurology Parkinsonism Positron emission tomography Science & Technology Vulnerability
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Beschreibung
Zusammenfassung:	•Nigral dopamine neuron is highly energy-consuming and vulnerable to stress.•Parkinsonism due to Kernohan notch rarely studied with functional imaging.•Loss of dopamine transporter uptake and preserved metabolism in striatum and midbrain.•Discrepancy between dopamine uptake and metabolism suggests selective vulnerability.
ISSN:	0022-510X 1878-5883
DOI:	10.1016/j.jns.2020.116946