The changing approach for identifying hereditary colorectal cancer syndromes

Data based on next-generation sequencing (NGS) of colorectal cancers (CRC) clearly show that up to 10% of all cases harbour pathogenic variants. Thus, NGS performed for all patients with CRC under the age of 50 could be a cost-effective strategy, leading to a personalized approach to patients and fa...

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Veröffentlicht in:	Nature reviews. Gastroenterology & hepatology 2020-10, Vol.17 (10), p.593-594
Hauptverfasser:	Laghi, Luigi, Ricciardiello, Luigi
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/2489/1512 692/4020/1503/1504/1885 Biomarkers, Tumor - genetics Biomedicine Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - diagnosis Colorectal Neoplasms - genetics Comment Diagnosis Early Detection of Cancer - methods Early Detection of Cancer - trends Gastroenterology Gastroenterology & Hepatology Genetic aspects Genetic disorders Genetic Predisposition to Disease Genetic Testing - methods Genetic Testing - trends Hepatology High-Throughput Nucleotide Sequencing - trends Humans Life Sciences & Biomedicine Medicine Medicine & Public Health Microsatellite Instability Mutation Neoplastic Syndromes, Hereditary - diagnosis Neoplastic Syndromes, Hereditary - genetics Next-generation sequencing Physiological aspects Precision Medicine - methods Precision Medicine - trends Science & Technology
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Beschreibung
Zusammenfassung:	Data based on next-generation sequencing (NGS) of colorectal cancers (CRC) clearly show that up to 10% of all cases harbour pathogenic variants. Thus, NGS performed for all patients with CRC under the age of 50 could be a cost-effective strategy, leading to a personalized approach to patients and family members.
ISSN:	1759-5045 1759-5053
DOI:	10.1038/s41575-020-0348-y