Indomethacin promotes browning and brown adipogenesis in both murine and human fat cells

Indomethacin (Indo), a nonsteroidal antiinflammatory drug, has been shown to promote murine brown adipogenesis both in vitro and in vivo, possibly due to its peroxisome proliferator‐activated receptor gamma (PPARγ)‐agonist activities. However, it is unclear whether Indo induces browning of white adi...

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Veröffentlicht in:	Pharmacology research & perspectives 2020-06, Vol.8 (3), p.e00592-n/a, Article 00592
Hauptverfasser:	Overby, Haley, Yang, Yang, Xu, Xinyun, Wang, Shu, Zhao, Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adipocytes Adipocytes, Brown - cytology Adipocytes, Brown - drug effects Adipocytes, White - cytology Adipocytes, White - drug effects Adipogenesis - drug effects Adrenergic receptors Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antibodies Apoptosis Body fat brown adipogenesis browning Cell culture Cell Differentiation - drug effects Cytochrome Deoxyribonucleic acid Diabetes DNA Dose-Response Relationship, Drug Female Gene Knockdown Techniques Humans indomethacin Indomethacin - administration & dosage Indomethacin - pharmacology Insulin Life Sciences & Biomedicine Lipids Metabolism Mice Mitochondrial DNA Obesity Original Pharmacology Pharmacology & Pharmacy PPAR gamma - agonists PPAR gamma - genetics PPAR gamma - metabolism PPARγ Proteins RNA, Messenger - metabolism Science & Technology Stains & staining
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