Low-Abundance Drug-Resistant HIV-1 Variants in Antiretroviral Drug-Naive Individuals: A Systematic Review of Detection Methods, Prevalence, and Clinical Impact

Abstract Background The presence of high-abundance drug-resistant HIV-1 jeopardizes success of antiretroviral therapy (ART). Despite numerous investigations, the clinical impact of low-abundance drug-resistant HIV-1 variants (LA-DRVs) at levels

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Veröffentlicht in:	The Journal of infectious diseases 2020-04, Vol.221 (10), p.1584-1597
Hauptverfasser:	Mbunkah, Herbert A, Bertagnolio, Silvia, Hamers, Raph L, Hunt, Gillian, Inzaule, Seth, Rinke De Wit, Tobias F, Paredes, Roger, Parkin, Neil T, Jordan, Michael R, Metzner, Karin J
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Anti-HIV Agents - pharmacology Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Drug resistance Drug Resistance, Viral - genetics Genetic Variation HIV HIV Infections - drug therapy HIV Infections - virology HIV-1 - drug effects HIV-1 - genetics Human immunodeficiency virus Humans Immunology Infectious Diseases Life Sciences & Biomedicine Microbiology Non-nucleoside reverse transcriptase inhibitors Reviews RNA-directed DNA polymerase Science & Technology
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Beschreibung
Zusammenfassung:	Abstract Background The presence of high-abundance drug-resistant HIV-1 jeopardizes success of antiretroviral therapy (ART). Despite numerous investigations, the clinical impact of low-abundance drug-resistant HIV-1 variants (LA-DRVs) at levels
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/jiz650