Penicillin Testing in Infants

Studies have shown that true penicillin allergy is rare in children and that most rashes are due to infectious exanthems.1 Because the reaction to amoxicillin/clavulanate was cutaneous only, it would be classified as a benign rash. Recent studies in children have shown that penicillin skin tests add little to the evaluation of benign penicillin reactions compared with direct challenge.2,3 One of the largest studies by Mill et al2 performed direct amoxicillin challenge in 818 children with an interquartile age from 2 to 7 years, which would indicate that 25% of children were